Demystified ...: Adhesion molecule deficiencies

Demystified...adhesion molecule deficiencies.

The basic physiology of leucocyte emigration from the intravascular space into the tissues is now known to be dependent on a class of cell surface molecules that have come to be known as adhesion molecules. Many cell-cell interactions are dependent on adhesion and signal transduction via the various adhesion molecules, particularly the integrins. The study of the functions of these molecules ha...

Soluble Intercellular Adhesion Molecule

Previous studies have suggested that intercellular ad¬ hesion molecule 1 (ICAM-1, CD54) may be involved in the pathogenesis ofasthma. In addition, a soluble form of ICAM-1 (sICAM-1) has been detected in increased concentrations in the sera of patients with certain in¬ flammatory conditions. To determine whether bron¬ chial asthma is associated with increased levels of sICAM-1 in serum and to as...

Setuid Demystified

Access control in Unix systems is mainly based on user IDs, yet the system calls that modify user IDs (uid-setting system calls), such as setuid, are poorly designed, insufficiently documented, and widely misunderstood and misused. This has caused many security vulnerabilities in application programs. We propose to make progress on the setuid mystery through two approaches. First, we study kern...

Microarrays demystified.

Fibroblast activation protein (FAP), as described so far, is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds. We investigated the expression of FAP by fibroblast-like synoviocytes (FLSs) and compared the synovial expression pattern in rheumatoid arthritis (RA) and osteoarthritis (OA) patients. S...

Intercellular Adhesion Molecule-1 Deficiency